5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione

Base Information

Chemical Name:5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione
CAS No.:1133820-07-1
Molecular Formula:C₁₈H₁₆FNO₄S
Molecular Weight:361.394
Hs Code.:

Synonyms:5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione

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Chemical Property of 5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione

Chemical Property:

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Technology Process of 5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione

There total 4 articles about 5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1133820-06-0
5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzylidene}-1,3-thiazolidine-2,4-dione

: 1133820-07-1
5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione

Guidance literature:: With sodium tetrahydroborate; water; acetic acid; [2,2]bipyridinyl; cobalt(II) chloride; In tetrahydrofuran;

Reference yield:

: 350-51-6
3-fluorostyrene

: 1133820-07-1
5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; N-Bromosuccinimide / water; 1,4-dioxane / 4 h / 0 - 20 °C

1.2: 20 °C

2.1: sodium hydroxide / toluene; water / 78 °C

3.1: piperidine / ethanol / 6 h / Reflux

4.1: cobalt(II) chloride hexahydrate; sodium tetrahydroborate; acetic acid; [2,2]bipyridinyl / water; tetrahydrofuran

With piperidine; [2,2]bipyridinyl; sodium tetrahydroborate; N-Bromosuccinimide; cobalt(II) chloride hexahydrate; acetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene;

Reference yield:

: 1133820-05-9
4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzaldehyde

: 1133820-07-1
5-{4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzyl}-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / ethanol / 6 h / Reflux

2: cobalt(II) chloride hexahydrate; sodium tetrahydroborate; acetic acid; [2,2]bipyridinyl / water; tetrahydrofuran

With piperidine; [2,2]bipyridinyl; sodium tetrahydroborate; cobalt(II) chloride hexahydrate; acetic acid; In tetrahydrofuran; ethanol; water;