3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine

Base Information

Chemical Name:3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine
CAS No.:136386-57-7
Molecular Formula:C₁₅H₂₃F₃N₂OSi
Molecular Weight:332.441
Hs Code.:

Synonyms:3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine

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Chemical Property of 3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine

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Technology Process of 3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine

There total 6 articles about 3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 136386-78-2
O-(4-Toluenesulphonyl)-1-(3-t-butyldimethylsilyloxy-5-methylphenyl)-2,2,2-trifluoroethanone oxime

: 136386-57-7
3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine

Guidance literature:: With ammonia; In diethyl ether; at -78 ℃; for 6h;
DOI:10.1016/S0040-4020(01)80991-1

Reference yield:

: 74204-00-5
3-bromo-5-methylphenol

: 136386-57-7
3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 1 h / Ambient temperature

2: 1) BuLi / 1) THF, -78 deg C, 1 h; 2) THF, -78 deg C, 2 h

3: 100 percent / NH₂OH*HCl, pyridine / ethanol / 4 h / Heating

4: pyridine / 2 h / Heating

5: 38 percent / NH₃ / diethyl ether / 6 h / -78 °C

With pyridine; n-butyllithium; hydroxylamine hydrochloride; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)80991-1

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 136386-57-7
3-(3-t-Butyldimethylsilyloxy-5-methylphenyl)-3-trifluoromethyl-3H-diaziridine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 1 h / Ambient temperature

2: 1) BuLi / 1) THF, -78 deg C, 1 h; 2) THF, -78 deg C, 2 h

3: 100 percent / NH₂OH*HCl, pyridine / ethanol / 4 h / Heating

4: pyridine / 2 h / Heating

5: 38 percent / NH₃ / diethyl ether / 6 h / -78 °C

With pyridine; n-butyllithium; hydroxylamine hydrochloride; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)80991-1