(E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate

Base Information

• Chemical Name: (E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate
• CAS No.: 944419-74-3
• Molecular Formula: C₂₃H₂₉NO₃
• Molecular Weight: 367.488
• Mol file: 944419-74-3.mol

Synonyms:(E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate

Chemical Property of (E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate

There total 2 articles about (E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-isobutoxyphenyl)N,N-dimethylmethanamine (944419-51-6) + benzylacrylate (2495-35-4,25036-21-9) → (E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate (944419-74-3)

Guidance literature:

With copper diacetate; acetic acid; palladium dichloride; In 2,2,2-trifluoroethanol; at 85 ℃; for 48h;

DOI:10.1021/ja070588a

Reference yield:

2-(i-butoxy)benzaldehyde (81995-32-6) → (E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate (944419-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NEt₃; Ti(i-PrO)4 / ethanol / 12 h / 25 °C

1.2: NaBH₄ / ethanol / 10 h / 25 °C

2.1: 148 mg / Cu(OAc)2; AcOH / PdCl₂ / 2,2,2-trifluoro-ethanol / 48 h / 85 °C

With titanium(IV) isopropylate; copper diacetate; acetic acid; triethylamine; palladium dichloride; In ethanol; 2,2,2-trifluoroethanol;

DOI:10.1021/ja070588a

Reference yield:

(E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate (944419-74-3) → C21H26O3

Guidance literature:

With hydrogen; palladium on activated charcoal; In 2-methoxy-ethanol; at 55 ℃; for 22h;

DOI:10.1021/ja070588a

upstream raw materials:

(2-isobutoxyphenyl)N,N-dimethylmethanamine

benzylacrylate

2-(i-butoxy)benzaldehyde