2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate

Base Information

Chemical Name:2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate
CAS No.:249572-38-1
Molecular Formula:C₄₁H₅₂N₁₀O₁₇P₂
Molecular Weight:1018.87
Hs Code.:

Synonyms:2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate

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Chemical Property of 2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate

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Technology Process of 2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate

There total 8 articles about 2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 249572-36-9
2,2-dimethoxypropionyl cyanoethyl N-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate

: 249572-38-1
2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: With acetic acid; at 20 ℃; for 2h;
DOI:10.1021/ja991574a

Reference yield:

: 99547-44-1
hydroxyacetone dimethylacetal

: 249572-38-1
2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrazole; 4A-molecular sieves / acetonitrile / 1.5 h / 0 - 20 °C

2: I₂; H₂O; pyridine / tetrahydrofuran / 0.33 h / 20 °C

3: 93 percent / aq. AcOH / 2 h / 20 °C

4: tetrazole / acetonitrile / 1.5 h / 0 - 20 °C

5: I₂; H₂O; pyridine / tetrahydrofuran / 0.33 h / 20 °C

6: 98 percent / aq. AcOH / 2 h / 20 °C

With pyridine; 1H-tetrazole; 4 A molecular sieve; water; iodine; acetic acid; In tetrahydrofuran; acetonitrile; 1: Condensation / 2: Oxidation / 3: Hydrolysis / 4: Condensation / 5: Oxidation / 6: Hydrolysis;
DOI:10.1021/ja991574a

Reference yield:

: 10076-48-9
methyl 2,2-dimethoxypropionate

: 249572-38-1
2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / lithium aluminum hydride / diethyl ether / 1 h / 20 °C

2: tetrazole; 4A-molecular sieves / acetonitrile / 1.5 h / 0 - 20 °C

3: I₂; H₂O; pyridine / tetrahydrofuran / 0.33 h / 20 °C

4: 93 percent / aq. AcOH / 2 h / 20 °C

5: tetrazole / acetonitrile / 1.5 h / 0 - 20 °C

6: I₂; H₂O; pyridine / tetrahydrofuran / 0.33 h / 20 °C

7: 98 percent / aq. AcOH / 2 h / 20 °C

With pyridine; 1H-tetrazole; lithium aluminium tetrahydride; 4 A molecular sieve; water; iodine; acetic acid; In tetrahydrofuran; diethyl ether; acetonitrile; 1: Reduction / 2: Condensation / 3: Oxidation / 4: Hydrolysis / 5: Condensation / 6: Oxidation / 7: Hydrolysis;
DOI:10.1021/ja991574a