10076-48-9

Usage

Uses

Used in Chemical Synthesis:
2,2-Dimethoxypropionic acid methyl ester is used as a chemical intermediate for the synthesis of various compounds, facilitating the creation of a range of products across different industries.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2,2-Dimethoxypropionic acid methyl ester is used as a building block in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Solvent Applications:
As a solvent, 2,2-Dimethoxypropionic acid methyl ester is employed across various industries to dissolve and process other substances, enhancing the efficiency of chemical reactions and manufacturing processes.
Used in Polymer and Coating Production:
2,2-Dimethoxypropionic acid methyl ester is used as a stabilizer and crosslinking agent in the production of polymers and coatings, improving the durability and performance of these materials.
Used in Organic Synthesis:
In organic synthesis, 2,2-Dimethoxypropionic acid methyl ester is utilized as a reagent, playing a crucial role in the formation of complex organic molecules and compounds.

Upstream product

• 67-56-1 methanol 
• 600-22-6 pyruvic acid methyl ester 
• 149-73-5 trimethyl orthoformate 
• 1069-12-1 1,1,2,2-tetramethoxyethylene 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 7647-01-0 hydrogenchloride 
• 7001-18-5 methyl 2-methoxyacrylate 
• 127-17-3 2-oxo-propionic acid 
• 683-70-5 3-chloro-but-3-en-2-one 
• 1809-02-5 2-chloro-3-methylbutadiene 
• 89-91-8 Methyl dimethoxyacetate 
• 74-88-4 methyl iodide 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 1184174-08-0 C₁₂H₂₁NO₅ 
• 942190-66-1 3-methoxy-pyrrolidine-3-carboxylic acid methyl ester 
• 942190-65-0 1-benzyl-3-methoxy-pyrrolidine-3-carboxylic acid methyl ester 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 67-56-1 methanol 
• 881910-49-2 N-(2-hydroxyethyl)-N-methyl-2,2-dimethoxypropionic acid amide 
• 76391-12-3 1-pyruvyl-L-proline 
• 249572-36-9 2,2-dimethoxypropionyl cyanoethyl N-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate 
• 249572-38-1 2,2-dimethoxypropionyl cyanoethyl N-benzoyl-2'-deoxy-P-cyanoethylcytidylyl-(3'-5')-N-isobutyryl-2'-deoxy-3'-guanylate 
• 249572-34-7 2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate 
• 6285-28-5 4-amino-3,5-diethyl-1,2,4-triazole 
• 141763-09-9 2,2-dimethoxypropionohydrazide 
• 141763-08-8 4-amino-3,5-bis(1,1-dimethoxyethyl)-4H-1,2,4-triazole 
• 154406-06-1 1-(8-Benzyloxy-7-bromo-quinolin-2-yl)-ethanone 

Relevant academic research and scientific papers

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer

Capping off an era marred by drug development failures and punctuated by waning interest and presumed intractability toward direct targeting of KRAS, new technologies and strategies are aiding in the target's resurgence. As previously reported, the tetrahydropyridopyrimidines were identified as irreversible covalent inhibitors of KRASG12C that bind in the switch-II pocket of KRAS and make a covalent bond to cysteine 12. Using structure-based drug design in conjunction with a focused in vitro absorption, distribution, metabolism and excretion screening approach, analogues were synthesized to increase the potency and reduce metabolic liabilities of this series. The discovery of the clinical development candidate MRTX849 as a potent, selective covalent inhibitor of KRASG12C is described.

HEXAMETHOXYCYCLOPROPANE

Hexamethoxycyclopropane, obtained by reaction of lithiopentamethoxycyclopropane with dimethyl peroxide, decomposes at 200 deg C to dimethoxycarbene and tetramethoxyethylene.

A selective method for the preparation of aliphatic methyl esters in the presence of aromatic carboxylic acids

2,2-Dimethoxypropane, methanol and a catalytic amount of HCl selectively esterify aliphatic carboxylic acids, in the presence of aromatic carboxylic acids, at room temperature and in high yields.

HERBICIDAL AND FUNGICIDAL 5-OXY-SUBSTITUTED 3-PHENYLISOXAZOLINE-5-CARBOXAMIDES AND 5-OXY-SUBSTITUTED 3-PHENYLISOXAZOLINE-5-THIOAMIDES

Herbicidally and fungicidally active 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides of the formula (I) are described. In this formula (I), X, X2 to X6, R1 to R4 are radicals such as hydrogen, halogen and organic radicals such as substituted alkyl. A is a bond or a divalent unit. Y is a chalcogen.

Dissolution of wood in α-keto acid and aldehydic carboxylic acids and fractionation at room temperature

Wood pulverised using a ball mill was dissolved in an α-keto acid, pyruvic acid, and two aldehydic carboxylic acids, namely glyoxylic acid and formic acid, at room temperature. Viscosity and optical transmittance analyses revealed that the wood particles dissolved in glyoxylic acid and formic acid in several hours, while they dissolved in pyruvic acid in several days. Size exclusion chromatography demonstrated that substances with number average molecular mass exceeding 105 were present in every solution. Incubation of these carboxylic acids with methanol produced the corresponding ester and/or (hemi)acetal derivatives, suggesting that the dissolution mechanism involves the substitution of hydroxyl groups in biomass. After dissolution, all solutions demonstrated non-Newtonian fluid behaviour with a non-Newtonian index n ranging from 0.41 to 0.72. When the dissolution time increased, the non-Newtonian index of the formic acid solution increased towards the value for a Newtonian fluid (n = 1). This rise was accompanied by partial depolymerisation. Evaporation of the wood solution gave a smooth transparent film. Using the water-immiscible solvent 2-methyltetrahydrofuran (2-MeTHF), the formic acid solution was separated into cellulosic porous solids, lignin-rich 2-MeTHF-soluble fraction and other components at room temperature. The dissolution of woody biomass at room temperature creates a new biorefinery process for the conversion of wood components in various solution reactions. In particular, in this study, pyruvic acid, which plays a central role in the metabolism of living organisms, is used as a new solvent for wood, thus bridging biochemistry and wood biorefinery. This journal is the Partner Organisations 2014.

COMPOUNDS THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, and solvates thereof. Q is a tetrahydopyridinyl ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

MONOMER COMPOUND, PROCESS FOR PRODUCING THE SAME, POLYMER THEREOF, AND WATER-BASED CURABLE COMPOSITION

The present invention provides an α-oxoamide group-and (meth)acryloyloxy group-containing monomer compound represented by Formula (I) wherein Y is a C1-6 straight-chain alkylene group which may be substituted with a C1-6 organic group, R1 is a C1-16 organic group, R2 is a hydrogen atom or a C1-8 organic group, and R3 is a hydrogen atom or a methyl group; a production process therefor; a polymer thereof; and an aqueous curable composition containing the polymer.

METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE BONE DISORDERS

The present disclosure provides methods and compositions using Syk inhibitory compounds for treating degenerative bone disorders and as prophylactic treatment to prevent bone loss. These treatments may reduce the fracture risk associated with bone loss and compromised bone strength.

Towards the synthesis of osteoclast inhibitor SB-242784

Osteoclast inhibitor SB-242784 (1) was prepared from pivotal indol intermediate 4. A 'Stille' cross coupling of organotin 2c with bromo acrylate 11 afforded diene 12 which was also obtained via a reduction-isomerization process of enyne 16. Bromoamide 3 was prepared from the corresponding acid 7 which was readily obtained from bromopyruvic acid.

3-(2-Pyrrolidinyl)-2,4-furandione Analogs

The reaction of 4,4-dimethyl-3-oxobutanoic (or pentanoic) acid esters with the lactim ether of 2-pyrrolidone in the presence of 2-hydroxypyridine produces condensation products 4 in 57-72percent yield.Acidic hydrolysis of 4 affords the furandione system 5 in 75-81percent yield.