Methyl 2,2-dimethoxypropanoate

Base Information

• Chemical Name: Methyl 2,2-dimethoxypropanoate
• CAS No.: 10076-48-9
• Molecular Formula: C6H12 O4
• Molecular Weight: 148.159
• Hs Code.: 2918990090
• European Community (EC) Number: 233-211-3
• NSC Number: 159637
• DSSTox Substance ID: DTXSID60143503
• Nikkaji Number: J241.257H
• Wikidata: Q63409283
• Mol file: 10076-48-9.mol

Synonyms:methyl 2,2-dimethoxypropanoate;10076-48-9;2,2-Dimethoxypropionic Acid Methyl Ester;Methyl 2,2-dimethoxypropionate;Propanoic acid, 2,2-dimethoxy-, methyl ester;Methyl pyruvate dimethyl acetal;2,2-Dimethoxypropanoic acid methyl ester;Methyl (2,2-dimethoxy)pyruvate;Methyl (2,2-dimethoxy)propanoate;EINECS 233-211-3;MFCD00048066;methyl dimethoxypropionate;Methyl pyruvate dimethylacetal;methyl2,2-dimethoxypropanoate;SCHEMBL614248;KHQQDBIXHUJARJ-UHFFFAOYSA-;DTXSID60143503;NSC159637;AKOS016009499;DS-5713;NSC 159637;NSC-159637;SY053487;Propanoic acid,2-dimethoxy-, methyl ester;CS-0094869;D2382;FT-0636627;EN300-97309;O11855;A897345;Q63409283;1-(2-HYDROXY-ETHYL)-2-METHYL-1H-BENZOIMIDAZOLE-5-CARBOXYLICACID

Chemical Property of Methyl 2,2-dimethoxypropanoate

Chemical Property:

• Refractive Index: 1.4100-1.4120
• Boiling Point: 183.1°Cat760mmHg
• Flash Point: 67.6°C
• PSA: 44.76000
• Density: 1.03g/cm³
• LogP: 0.16840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 148.07355886
• Heavy Atom Count: 10
• Complexity: 117

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2,2-Dimethoxypropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)OC)(OC)OC

Technology Process of Methyl 2,2-dimethoxypropanoate

There total 18 articles about Methyl 2,2-dimethoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

pyruvic acid methyl ester (600-22-6) + trimethyl orthoformate (149-73-5) → methyl 2,2-dimethoxypropionate (10076-48-9)

Guidance literature:

With sulfuric acid; In methanol; for 5h; Heating;

DOI:10.1021/ja00345a059

Reference yield: 92.0%

methanol (67-56-1) + 2-oxo-propionic acid (127-17-3) → methyl 2,2-dimethoxypropionate (10076-48-9)

Guidance literature:

With chloro-trimethyl-silane; at 22 ℃;

DOI:10.1055/s-1983-30279

Reference yield: 92.0%

methanol (67-56-1) + pyruvic acid methyl ester (600-22-6) → methyl 2,2-dimethoxypropionate (10076-48-9)

Guidance literature:

With chloro-trimethyl-silane; for 18h; Ambient temperature;

DOI:10.1055/s-1983-30279

upstream raw materials:

methyl 2-methoxyacrylate

methanol

pyruvic acid methyl ester

trimethyl orthoformate

Downstream raw materials:

2,2-dimethoxy-propionic acid amide

1-(8-Benzyloxy-7-bromo-quinolin-2-yl)-ethanone

4-amino-3,5-diethyl-1,2,4-triazole

2,2-dimethoxypropionohydrazide

Refernces

• 1、 Moss, Robert A.,Cox, D. Phillip. "HEXAMETHOXYCYCLOPROPANE". . p. 1931 - 1934. Retrieved 1985.
• 2、 Rodriguez,Nomen,Spur,Godfroid. "A selective method for the preparation of aliphatic methyl esters in the presence of aromatic carboxylic acids". . p. 8563 - 8566. Retrieved 1998.
• 3、 Owen,Somade. "". . p. 1053. Retrieved 1947.
• 4、 Nishiwaki-Akine, Yuri,Watanabe, Takashi. "Dissolution of wood in α-keto acid and aldehydic carboxylic acids and fractionation at room temperature". . p. 3569 - 3579. Retrieved 2014/07/08.