8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester

Base Information

Chemical Name:8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester
CAS No.:1373491-81-6
Molecular Formula:C₂₅H₃₄ClNO₃
Molecular Weight:432.003
Hs Code.:

Synonyms:8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester

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Chemical Property of 8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester

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Technology Process of 8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester

There total 9 articles about 8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.3%

: 4,5,6,7-tetrahydrofuro[3,2-c]pyridine hydrochloride

: 1373492-37-5
8-bromo-8-(2-chlorophenyl)-2,2-dimethyloctanoic acid ethyl ester

: 1373491-81-6
8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 72h; Inert atmosphere;

Reference yield:

: 1121-46-6
2-Furan-2-yl-ethylamine

: 1373491-81-6
8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: water / 0.5 h / 20 °C

2.1: hydrogenchloride / N,N-dimethyl-formamide / Saturated solution

2.2: pH 11

3.1: dichloromethane / 1.5 h / 20 °C

4.1: hydrogenchloride / methanol / 5.5 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 60 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 150322-87-5
4,5,6,7-tetrahydrofuro[3,2.-c]pyridine

: 1373491-81-6
8-(2-chlorophenyl)-8-(6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl)-2,2-dimethyloctanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1.5 h / 20 °C

2: hydrogenchloride / methanol / 5.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 72 h / 60 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;