N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide

Base Information

Chemical Name:N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide
CAS No.:1338220-66-8
Molecular Formula:C₂₆H₂₃N₃O₃
Molecular Weight:425.487
Hs Code.:

Synonyms:N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide

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Chemical Property of N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide

Chemical Property:

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Technology Process of N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide

There total 4 articles about N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144-55-8
sodium hydrogencarbonate

: 1338220-66-8
N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide

Guidance literature:: With boron tribromide; In dichloromethane;

Reference yield:

: 1338221-31-0
N-[3-benzyl-5-(4-methoxyphenyl)pyrazin-2-yl]-2-(4-methoxyphenyl)propanamide

: 1338220-66-8
N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide

Guidance literature:: With boron tribromide; In dichloromethane; for 21h; Inert atmosphere; Reflux;

Reference yield:

: 942-54-1
2-(4-methoxyphenyl)propanoic acid

: 1338220-66-8
N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 27 h / Inert atmosphere; Reflux

2: dmap; pyridine / 14 h / 55 °C

3: boron tribromide / dichloromethane / 21 h / Inert atmosphere; Reflux

With pyridine; dmap; thionyl chloride; boron tribromide; In dichloromethane;