1-benzyloxymethyl-2-methylbenzimidazole

Base Information

Chemical Name:1-benzyloxymethyl-2-methylbenzimidazole
CAS No.:191097-61-7
Molecular Formula:C₁₆H₁₆N₂O
Molecular Weight:252.316
Hs Code.:

Synonyms:1-benzyloxymethyl-2-methylbenzimidazole

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Chemical Property of 1-benzyloxymethyl-2-methylbenzimidazole

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Technology Process of 1-benzyloxymethyl-2-methylbenzimidazole

There total 1 articles about 1-benzyloxymethyl-2-methylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 615-15-6
2-Methyl-1H-benzimidazole

: 3587-60-8
Benzyloxymethyl chloride

: 191097-61-7
1-benzyloxymethyl-2-methylbenzimidazole

Guidance literature:: In acetonitrile; for 3h; Heating;
DOI:10.1080/07328309708006530

Reference yield: 91.0%

: 13096-62-3
(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one

: 191097-61-7
1-benzyloxymethyl-2-methylbenzimidazole

: 191097-62-8
3,4,5,7-tetra-O-benzyl-1-[2-(1-benzyloxymethyl)benzimidazolyl]-1-deoxy-α-D-gluco-2-heptulopyranose

Guidance literature:: 1-benzyloxymethyl-2-methylbenzimidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -85 ℃; for 0.333333h;

(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one; In tetrahydrofuran; hexane; at -85 ℃; for 0.5h;
DOI:10.1080/07328309708006530

Reference yield:

: 191097-61-7
1-benzyloxymethyl-2-methylbenzimidazole

: 2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-[2-(1-benzyloxymethyl)benzimidazolyl]-1-deoxy-D-gluco-hept-2-enitol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -85 °C

1.2: 91 percent / tetrahydrofuran; hexane / 0.5 h / -85 °C

2.1: 93 percent / sodium hydride / dimethylformamide / 0.5 h / 0 °C

3.1: 69 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 30 h / 60 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetonitrile; 1.1: Metallation / 1.2: Addition / 2.1: Acetylation / 3.1: Elimination;
DOI:10.1080/07328309708006530