1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene

Base Information

• Chemical Name: 1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene
• CAS No.: 82112-31-0
• Molecular Formula: C₁₉H₃₆O₂Si₂
• Molecular Weight: 352.665
• Mol file: 82112-31-0.mol

Synonyms:1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene

Chemical Property of 1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene

There total 4 articles about 1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

salicylic alcohol (90-01-7) + N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide (77377-52-7) → 1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene (82112-31-0)

Guidance literature:

With tert-butyldimethylsilyl chloride; In acetonitrile; for 0.0833333h; Ambient temperature; other silylating agent;

DOI:10.1021/jo00138a032

Reference yield: 88.0%

salicylic alcohol (90-01-7) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene (82112-31-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(00)78344-4

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 1-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)benzene (82112-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hydride / 1.) benzene, acetonitrile, 4 deg C, 4 h, 2.) 2 h

2: 100 percent / 1percent tert-butyldimethylsilyl chloride (TBDMSCl) / acetonitrile / 0.08 h / Ambient temperature; other silylating agent

With sodium hydride; tert-butyldimethylsilyl chloride; In acetonitrile;

DOI:10.1021/jo00138a032

upstream raw materials:

salicylic alcohol

N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide

tert-butyldimethylsilyl chloride

{2-[(tert-butyldimethylsilyl)oxy]phenyl}methanol

Downstream raw materials:

salicylic alcohol

2-(((tert-butyldimethylsilyl)oxy)methyl)phenol

{2-[(tert-butyldimethylsilyl)oxy]phenyl}methanol

tert-butyl-(2-methoxy-benzyloxy)-dimethyl-silane