1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

Base Information

Chemical Name:1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid
CAS No.:117138-55-3
Molecular Formula:C₁₉H₁₅NO₃
Molecular Weight:305.333
Hs Code.:

1-benzoyl-1,2,2a,3-tetrahydrobenz<cd>indole-5-carboxylic acid

Synonyms:1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

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Chemical Property of 1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

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Technology Process of 1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

There total 1 articles about 1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 98-88-4
benzoyl chloride

: 1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

: 117138-55-3
1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; for 1h; Ambient temperature;
DOI:10.1248/cpb.35.4793

Reference yield: 100.0%

: 117138-55-3
1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

: 107183-50-6
1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carbonyl chloride

Guidance literature:: With thionyl chloride; In benzene; at 95 ℃; for 2.5h;
DOI:10.1248/cpb.35.4793

Reference yield:

: 117138-55-3
1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

: 117138-60-0
ethyl 3-methyl-6-(1-benzoyl-1,2,2a,3-tetrahydrobenzindol-5-yl)-2-oxo-3,4,5,6-tetrahydro-1,3-oxazine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / SOCl₂ / benzene / 2.5 h / 95 °C

2: 54 percent / H₂ / 10percent Pd-BaSO₄ / ethyl acetate; xylene / 2 h / 90 - 100 °C

3: 99 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

4: TEA / CH₂Cl₂ / 0.25 h / Ambient temperature

With thionyl chloride; TEA; hydrogen; lithium diisopropyl amide; palladium on barium sulfate; In tetrahydrofuran; dichloromethane; ethyl acetate; xylene; benzene;
DOI:10.1248/cpb.35.4793