4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile

Base Information

• Chemical Name: 4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile
• CAS No.: 224320-82-5
• Molecular Formula: C₂₁H₁₅ClN₂OS
• Molecular Weight: 378.882

Synonyms:4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile

Chemical Property of 4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile

Chemical Property:

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Technology Process of 4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile

There total 2 articles about 4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-(4-chlorophenyl)-3-cyano-6-methylpyridine-2(1H)-thione (94639-14-2) + α-bromoacetophenone (70-11-1) → 4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile (224320-82-5)

Guidance literature:

With sodium methylate; In methanol; for 5h; Heating;

DOI:10.1080/10426509908037022

Reference yield:

methyl 4-chlorocinnamate (7560-44-3,20754-21-6,20754-24-9) → 4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile (224320-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / Et₃N / methanol / 5 h / Heating

2: 81 percent / NaOMe / methanol / 5 h / Heating

With sodium methylate; triethylamine; In methanol; 1: cyclocondensation / 2: Alkylation;

DOI:10.1080/10426509908037022

Reference yield: 84.0%

4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile (224320-82-5) → [3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridin-2-yl]-phenyl-methanone

Guidance literature:

With potassium hydroxide; In ethanol; for 5h; Heating;

DOI:10.1080/10426509908037022

upstream raw materials:

4-(4-chlorophenyl)-3-cyano-6-methylpyridine-2(1H)-thione

α-bromoacetophenone

methyl 4-chlorocinnamate

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