1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione
CAS No.:256949-50-5
Molecular Formula:C₃₅H₄₅N₃O₉Si
Molecular Weight:679.843
Hs Code.:

1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Synonyms:1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

There total 5 articles about 1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 65-71-4,28806-14-6,691841-57-3
thymin

: (R)-5-Acetoxy-2-[(3aR,4R,6R,6aR)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-isoxazolidine-3-carboxylic acid ethyl ester

: 256949-49-2
1-[(3R,5S)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

: 256949-50-5
1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: thymin; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; for 0.25h; Heating;

(R)-5-Acetoxy-2-[(3aR,4R,6R,6aR)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-isoxazolidine-3-carboxylic acid ethyl ester; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 1h; Heating;
DOI:10.1016/S0957-4166(03)00499-3

Reference yield: 24.0%

: 65-71-4,28806-14-6,691841-57-3
thymin

: 256949-47-0
(3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

: 256949-49-2
1-[(3R,5S)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

: 256949-50-5
1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: thymin; With bis-(trimethylsilyl)acetamide; In acetonitrile; for 0.25h; Heating;

(3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 1h; Heating;
DOI:10.1021/jo990576a

Reference yield: 24.0%

: 65-71-4,28806-14-6,691841-57-3
thymin

: 256949-46-9
(3R,5R)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

: 256949-49-2
1-[(3R,5S)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

: 256949-50-5
1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: thymin; With bis-(trimethylsilyl)acetamide; In acetonitrile; for 0.25h; Heating;

(3R,5R)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 1h; Heating;
DOI:10.1021/jo990576a