(3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

Base Information

Chemical Name:(3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine
CAS No.:256949-47-0
Molecular Formula:C₃₂H₄₃NO₉Si
Molecular Weight:613.78
Hs Code.:

Synonyms:(3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

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Technology Process of (3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

There total 1 articles about (3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 108-05-4,9003-20-7
vinyl acetate

: 924-44-7
glyoxylic acid ethyl ester

: (4S,5R)-5-[(1R)-2-[[1-(tert-butyl)-1,1-diphenylsilyl]oxy]-1-hydroxyethyl]-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde oxime

: (3S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

: 256949-47-0
(3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

: 256949-46-9
(3R,5R)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

Guidance literature:: In toluene; at 60 ℃; for 14h;
DOI:10.1021/jo990576a

Reference yield: 24.0%

: 65-71-4,28806-14-6,691841-57-3
thymin

: 256949-47-0
(3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine

: 256949-49-2
1-[(3R,5S)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

: 256949-50-5
1-[(3R,5R)-2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonyl-1,2-isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: thymin; With bis-(trimethylsilyl)acetamide; In acetonitrile; for 0.25h; Heating;

(3R,5S)-5-acetyloxy-2-(5'-O-tert-butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-3-ethoxycarbonylisoxazolidine; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 1h; Heating;
DOI:10.1021/jo990576a