N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide

Base Information

Chemical Name:N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide
CAS No.:245365-11-1
Molecular Formula:C₂₅H₂₆ClFN₂O₄S
Molecular Weight:505.01
Hs Code.:

<i>N</i>-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide

Synonyms:N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide

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Chemical Property of N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide

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Technology Process of N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide

There total 5 articles about N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 245365-11-1
N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / pyridine

2: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

3: TFA / CH₂Cl₂

4: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With pyridine; polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

: 13518-40-6
L-valine tert-butylester hydrochloride

: 245365-11-1
N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / pyridine

2: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

3: TFA / CH₂Cl₂

4: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With pyridine; polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

: 245364-65-2
2-(4-fluoro-benzenesulfonylamino)-3-methyl-butyric acid tert-butyl ester

: 245365-11-1
N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

2: TFA / CH₂Cl₂

3: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X