Technology Process of 4-Chloro-2-fluoro-5-isopropoxymethyl-phenylamine
There total 6 articles about 4-Chloro-2-fluoro-5-isopropoxymethyl-phenylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
platinum on activated charcoal;
In
acetic acid;
for 0.5h;
under 2068.6 Torr;
Yield given;
DOI:10.1055/s-1987-28110
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 92 percent / Co(OAc)2*4H2O, Mn(OAc)2*4H2O, tert-butyl peroxide, 48percent HBr, O2 / acetic acid / 3 h / 130 - 160 °C / 15514.4 Torr
2: 83 percent / fuming HNO3, conc. H2SO4 / 0 deg C, 1 h then 50 deg C, 1.5 h
3: 93 percent / B2H6 / tetrahydrofuran / 1.5 h / Heating
4: 2,6-dimethylpyridine / CH2Cl2 / 1 h / 0 °C
5: K2CO3 / CH2Cl2 / 1 h / Ambient temperature
6: H2 / 5percent Pt/C / acetic acid / 0.5 h / 2068.6 Torr
With
2,6-dimethylpyridine; di-tert-butyl peroxide; sulfuric acid; hydrogen bromide; hydrogen; oxygen; nitric acid; cobalt(II) acetate; manganese(II) acetate; potassium carbonate; diborane;
platinum on activated charcoal;
In
tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1055/s-1987-28110
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83 percent / fuming HNO3, conc. H2SO4 / 0 deg C, 1 h then 50 deg C, 1.5 h
2: 93 percent / B2H6 / tetrahydrofuran / 1.5 h / Heating
3: 2,6-dimethylpyridine / CH2Cl2 / 1 h / 0 °C
4: K2CO3 / CH2Cl2 / 1 h / Ambient temperature
5: H2 / 5percent Pt/C / acetic acid / 0.5 h / 2068.6 Torr
With
2,6-dimethylpyridine; sulfuric acid; hydrogen; nitric acid; potassium carbonate; diborane;
platinum on activated charcoal;
In
tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1055/s-1987-28110
