methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

Base Information

Chemical Name:methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate
CAS No.:1356459-41-0
Molecular Formula:C₄₀H₃₉NO₁₁S
Molecular Weight:741.816
Hs Code.:

Synonyms:methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

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Technology Process of methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

There total 1 articles about methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 98-88-4
benzoyl chloride

: (2R,4S,5R,6R)-5-Acetylamino-4-hydroxy-2-p-tolylsulfanyl-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 1356459-41-0
methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

Guidance literature:: With pyridine; at 0 ℃; for 5h;
DOI:10.1021/ol3000475

Reference yield: 88.0%

: 1356459-41-0
methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

: 108-24-7
acetic anhydride

: 1356459-42-1
methyl [p-methylphenyl 7-O-acetyl-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

Guidance literature:: In pyridine; Inert atmosphere;
DOI:10.1021/ol3000475

Reference yield:

: 1356459-41-0
methyl [p-methylphenyl 5-acetamido-4,8,9-tri-O-benzoyl-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

: methyl 5-acetamido-7-O-acetyl-4,8,9-tri-O-benzoyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonate-(2->6)-1,2,3,4-di-O-isopropylidene-α-D-galactopyranoside

: methyl 5-acetamido-7-O-acetyl-4,8,9-tri-O-benzoyl-3,5-dideoxy-D-glycero-β-D-galacto-non-2-ulopyranosylonate-(2->6)-1,2,3,4-di-O-isopropylidene-α-D-galactopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / Inert atmosphere

2.1: dichloromethane / 16 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: -72 °C / Inert atmosphere

In pyridine; dichloromethane;
DOI:10.1021/ol3000475