(R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester

Base Information

Chemical Name:(R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester
CAS No.:178681-78-2
Molecular Formula:C₁₆H₂₂O₅
Molecular Weight:294.348
Hs Code.:

Synonyms:(R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester

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Chemical Property of (R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester

Chemical Property:

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Technology Process of (R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester

There total 8 articles about (R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: methyl (R)-(-)-4-ethoxycarbonyl-4-(m-methoxyphenyl)-4-methyl-2-butenoate

: 178681-78-2
(R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 20h;
DOI:10.3987/COM-96-7421

Reference yield:

: 35553-92-5
ETHYL 3-METHOXYPHENYLACETATE

: 178681-78-2
(R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 72 percent / NaH / benzene; paraffin / 2.5 h / Heating

2: 90 percent / 1.) NaH / paraffin; 1,2-dimethoxy-ethane / 18 h / Ambient temperature; 1.) room temp., 40 min

3: 70 percent / PLE, pH 8.04 phosphate buffer / acetone / 10 h / Ambient temperature

4: 96 percent / LiBH₄ / tetrahydrofuran / 1 h / 55 °C

5: 78 percent / sulfuric acid / benzene / 45 h / Heating

6: PCC, Celite / CH₂Cl₂ / 4 h / Ambient temperature

7: 1.) NaH / tetrahydrofuran; paraffin / 14 h / Ambient temperature; 1.) THF, mineral oil, room temp., 40 min

8: 97 percent / hydrogen / 5percent Pd/C / methanol / 20 h

With lithium borohydride; Celite; pH 8.04 phosphate buffer; sulfuric acid; hydrogen; sodium hydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetone; paraffin; benzene;
DOI:10.3987/COM-96-7421

Reference yield:

: 50874-07-2
2-(3-methoxyphenyl)malonic acid diethyl ester

: 178681-78-2
(R)-2-(3-Methoxy-phenyl)-2-methyl-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / 1.) NaH / paraffin; 1,2-dimethoxy-ethane / 18 h / Ambient temperature; 1.) room temp., 40 min

2: 70 percent / PLE, pH 8.04 phosphate buffer / acetone / 10 h / Ambient temperature

3: 96 percent / LiBH₄ / tetrahydrofuran / 1 h / 55 °C

4: 78 percent / sulfuric acid / benzene / 45 h / Heating

5: PCC, Celite / CH₂Cl₂ / 4 h / Ambient temperature

6: 1.) NaH / tetrahydrofuran; paraffin / 14 h / Ambient temperature; 1.) THF, mineral oil, room temp., 40 min

7: 97 percent / hydrogen / 5percent Pd/C / methanol / 20 h

With lithium borohydride; Celite; pH 8.04 phosphate buffer; sulfuric acid; hydrogen; sodium hydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetone; paraffin; benzene;
DOI:10.3987/COM-96-7421