1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate

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Chemical Name:1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate
CAS No.:113918-81-3
Molecular Formula:C₄₅H₆₇O₁₄P
Molecular Weight:862.992
Hs Code.:

1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate

Synonyms:1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate

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Chemical Property of 1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate

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Technology Process of 1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate

There total 20 articles about 1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 108470-13-9
5(R)-hydroxy-4(R)-(4-methoxybenzyl)oxymethyl-2-methyl-2(E)-heptenal

: 108470-14-0
(3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyloxy)ethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoic acid

: 113918-81-3
1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate

Guidance literature:: With dmap; 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; benzene; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(00)84872-8

Reference yield:

: 98039-10-2
3-deoxy-1,2,5,6-di-O-isopropylidene-3-C-(4-metoxybenzyloxymethyl)-α-D-allofuranose

: 113918-81-3
1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate

Guidance literature:: Multi-step reaction with 11 steps

1: 86.5 percent / 2percent H₂SO₄ / methanol / 15 h / Ambient temperature

2: Et₃N/DMAP / CH₂Cl₂ / 19 h / Ambient temperature

3: NaI / butan-2-one / 24 h / Heating

4: 98.5 percent / H₂ / 10percent Pd-C / 0.5 h

5: 70 percent / 4.5 N HCl / tetrahydrofuran / 5.5 h / 50 °C

6: 86 percent / Ca(BH₄)2 / ethanol / 1 h / Ambient temperature

7: 95 percent / NaIO₄ / methanol; H₂O / 1 h / Ambient temperature

8: 90 percent / ethanol / 10 h / 60 °C

9: 86 percent / LiAlH₄ / tetrahydrofuran / 1 h

10: 96 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

11: DMAP / benzene / 1 h / Ambient temperature

With hydrogenchloride; dmap; manganese(IV) oxide; sodium periodate; lithium aluminium tetrahydride; calcium borohydride; sulfuric acid; hydrogen; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; butanone; benzene;
DOI:10.1248/cpb.35.2219

Reference yield:

: 86654-47-9
(R)-1-[(3aR,5S,6R,6aR)-6-(4-Methoxy-benzyloxymethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol

: 113918-81-3
1(R)-ethyl-5-formyl-2(R)-(4-methoxybenzyloxy)oxymethyl-3(Z)-pentenyl (3R,4S,5S,6R,8R)-6-<2-(3,4-dimethoxybenzyl)oxyethyl>-10-(dimethoxyphosphono)-4,8-dimethyl-3,5-isopropylidenedioxy-9-oxodecanoate

Guidance literature:: Multi-step reaction with 10 steps

1: Et₃N/DMAP / CH₂Cl₂ / 19 h / Ambient temperature

2: NaI / butan-2-one / 24 h / Heating

3: 98.5 percent / H₂ / 10percent Pd-C / 0.5 h

4: 70 percent / 4.5 N HCl / tetrahydrofuran / 5.5 h / 50 °C

5: 86 percent / Ca(BH₄)2 / ethanol / 1 h / Ambient temperature

6: 95 percent / NaIO₄ / methanol; H₂O / 1 h / Ambient temperature

7: 90 percent / ethanol / 10 h / 60 °C

8: 86 percent / LiAlH₄ / tetrahydrofuran / 1 h

9: 96 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

10: DMAP / benzene / 1 h / Ambient temperature

With hydrogenchloride; dmap; manganese(IV) oxide; sodium periodate; lithium aluminium tetrahydride; calcium borohydride; hydrogen; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; butanone; benzene;
DOI:10.1248/cpb.35.2219