3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

Base Information

• Chemical Name: 3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester
• CAS No.: 359009-97-5
• Molecular Formula: C₃₈H₄₂N₂O₆
• Molecular Weight: 622.761
• Mol file: 359009-97-5.mol

Synonyms:3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

Chemical Property of 3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

There total 1 articles about 3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-Fmoc-β-alanine (35737-10-1) + 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol (172611-73-3) → 3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester (359009-97-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 24h;

DOI:10.1016/S0040-4020(02)00513-6

Reference yield:

3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester (359009-97-5) → 3-[3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester (359009-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₂NH₂ / dimethylformamide

2: 90 percent / EDCI / CH₂Cl₂ / 24 h / 20 °C

3: 46 percent / dimethylformamide / 24 h

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00513-6

Reference yield:

3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester (359009-97-5) → pentafluorophenyl 3-[[(9H-fluoren-9-yl)methyloxy]carbonylamino]propionate (149303-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂NH₂ / dimethylformamide

2: 90 percent / EDCI / CH₂Cl₂ / 24 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00513-6

upstream raw materials:

N-Fmoc-β-alanine

4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol

Downstream raw materials:

pentafluorophenyl 3-[[(9H-fluoren-9-yl)methyloxy]carbonylamino]propionate

3-[3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester