DMAB-OH

Base Information

• Chemical Name: DMAB-OH
• CAS No.: 172611-73-3
• Molecular Formula: C20H27 N O3
• Molecular Weight: 329.439
• Hs Code.: 2922 50 00
• Mol file: 172611-73-3.mol

Synonyms:DMAB-OH;4-(N-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEXYLIDENE)-3-METHYLBUTYL]-AMINO) BENZYL ALCOHOL;2(1(4-HYDROXYME)PHE.AMINO)-3-ME.BUTYLI-

Chemical Property of DMAB-OH

Chemical Property:

• Vapor Pressure: 3.91E-10mmHg at 25°C
• Melting Point: 156-160
• Refractive Index: 1.571
• Boiling Point: 482.9°C at 760 mmHg
• Flash Point: 245.8°C
• PSA: 66.40000
• Density: 1.132g/cm³
• LogP: 3.92220
• Storage Temp.: 0-6°C

Purity/Quality:

99% ^*data from raw suppliers

DMAB-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of DMAB-OH

There total 1 articles about DMAB-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-aminobenzenemethanol (623-04-1) + 2-(1-hydroxy-3-methylbutylidene)-5,5-dimethylcyclohexane-1,3-dione (172611-72-2) → 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol (172611-73-3)

Guidance literature:

In tetrahydrofuran; for 60h; Heating;

DOI:10.1039/c39950002209

Reference yield: 100.0%

BOC-glycine (4530-20-5) + 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol (172611-73-3) → tert-butoxycarbonylamino-acetic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(02)00513-6

Reference yield: 95.0%

N-Fmoc-β-alanine (35737-10-1) + 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol (172611-73-3) → 3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester (359009-97-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 24h;

DOI:10.1016/S0040-4020(02)00513-6

upstream raw materials:

4-aminobenzenemethanol

2-(1-hydroxy-3-methylbutylidene)-5,5-dimethylcyclohexane-1,3-dione

Downstream raw materials:

3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

N-α-Fmoc-O-tert-butyl-D-tyrosine 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester

Fmoc-Lys-ODmab

N-α-Fmoc-D-tyrosine 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester

Refernces