2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide
CAS No.:1285515-74-3
Molecular Formula:C₁₉H₁₄F₄N₂O₃
Molecular Weight:394.325
Hs Code.:

Synonyms:2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide

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Chemical Property of 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide

There total 4 articles about 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 354795-62-3
3-methylisoxazol-4-ylamine

: 1285517-55-6
2-{[(4-fluorophenyl)methyl]oxy}-5-(trifluoromethyl)benzoic acid

: 1285515-74-3
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 4864-01-1
2-methoxy-5-(trifluoromethyl)-benzoic acid

: 1285515-74-3
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Cyclohexyl iodide / N,N-dimethyl-formamide / 4 h / Reflux

2.1: potassium carbonate / acetone / Reflux

3.1: water; lithium hydroxide / tetrahydrofuran / 2 h / Reflux

3.2: pH 1

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With Cyclohexyl iodide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

Reference yield:

: 79427-88-6
2-hydroxy-5-(trifluoromethyl)benzoic acid

: 1285515-74-3
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / Reflux

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / Reflux

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;