2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester

Base Information

• Chemical Name: 2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester
• CAS No.: 243861-05-4
• Molecular Formula: C₁₇H₂₂O₆
• Molecular Weight: 322.358
• Mol file: 243861-05-4.mol

Synonyms:2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester

Chemical Property of 2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester

There total 2 articles about 2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl α-bromo-α-phenylacetate (35132-16-2) + malonic acid dimethyl ester (108-59-8) → 2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester (243861-05-4)

Guidance literature:

With sodium methylate; In methanol; for 1.5h; Heating;

DOI:10.1080/00397919908086464

Reference yield: 31.0%

tert-butyl 2-diazo-2-phenylacetate (72410-67-4) + malonic acid dimethyl ester (108-59-8) → 2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester (243861-05-4)

Guidance literature:

With copper(l) cyanide; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; tricyclohexylphosphine; In chloroform; at 60 ℃; for 1h;

DOI:10.1002/cctc.202000684

Reference yield: 99.0%

2-methoxycarbonyl-3-phenyl-butanedioic acid-4-tert-butyl-1-methyl ester (243861-05-4) → 2-methoxycarbonyl-3-phenyl-butanedioic acid (243861-06-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1080/00397919908086464

upstream raw materials:

tert-butyl α-bromo-α-phenylacetate

malonic acid dimethyl ester

tert-butyl 2-diazo-2-phenylacetate

Downstream raw materials:

2-methoxycarbonyl-3-phenyl-butanedioic acid

4-methyl-3-phenyl-2,5-dihydrofuran-2-one