35132-16-2

Upstream product

• 4870-65-9 2-bromophenylacetic acid 
• 75-65-0 tert-butyl alcohol 
• 540-88-5 acetic acid tert-butyl ester 
• 115-11-7 isobutene 
• 19078-72-9 bromo(phenyl)acetyl chloride 

Downstream Products

• 1010445-50-7 ethyl 3-(tert-butoxycarbonylphenylmethyl)-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate 
• 1010445-59-6 tert-butyl 3-(tert-butoxycarbonylphenylmethyl)-5-chloro-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate 
• 1010445-64-3 tert-butyl 3-(tert-butoxycarbonylphenylmethyl)-5-iodo-2-oxo-2,3-dihydro-benzimidazole-1-carboxylate 
• 1010445-69-8 tert-butyl 3-(tert-butoxycarbonylphenylmethyl)-5-cyano-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate 
• 39801-62-2 N-(trifluoroacetyl)phenylglycine 
• 53934-78-4 2-aminophenylacetic acid tert-butyl ester 
• 2835-06-5 phenylglycin 
• 159591-42-1 t-butyl 2-[(4-carbomethoxy-2,6-dipropyl)phenoxy]-2-phenylacetate 
• 1384745-30-5 [benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester 
• 1384745-32-7 1-benzyl-2-phenyl-azetidine-2-carboxylic acid tert-butyl ester 
• 1384745-27-0 [benzyl-(2-hydroxyethyl)-amino]-phenyl-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Multiple Absolute Stereocontrol in Cascade Lactone Formation via Dynamic Kinetic Resolution Driven by the Asymmetric Transfer Hydrogenation of Keto Acids with Oxo-Tethered Ruthenium Catalysts

A straightforward asymmetric construction of chiral fused γ- and δ-lactones containing multiple contiguous stereocenters was successfully developed by either (1) the dynamic kinetic resolution-asymmetric transfer hydrogenation (DKR-ATH) reaction using oxo

PROTECTED ORGANOBORONIC ACIDS WITH TUNABLE REACTIVITY, AND METHODS OF USE THEREOF

Disclosed are a range of protected organoboronic acid reagents useful in the modular assembly of complex organic compounds. The reactivities of the protected organoboronic acid reagents may be varied predictably by changes to the number and identities of their substituents. Also disclosed are methods of using the protected organoboronic acid reagents in the synthesis of organic compounds.

Practical preparation of enantiopure 2-methyl-azetidine-2-carboxylic acid; a γ-turn promoter

A robust and practical synthesis of each enantiomer of 2-methyl-azetidine- 2-carboxylic acid, based on the use of (S)-phenylglycinol as resolving agent, is described. This synthesis affords practical quantities of this quaternary amino acid suitably N- an

Ethynyl-1,2-benziodoxol-3(1H)-one (EBX): An exceptional reagent for the ethynylation of keto, cyano, and nitro esters

Hot alkyne! The in situ generation of ethynyl-1,2-benziodoxol-3(1H)-one (EBX) from a silyl-protected reagent by using TBAF is reported. EBX displayed exceptional acetylene transfer ability onto stabilized enolates (see scheme), even at -78 □°C. The mild reaction conditions allowed the first ethynylation reactions of linear keto, cyano, and nitro esters in high yields to give all-carbon quaternary centers or non-natural amino acids after selective reduction of the nitro group.

SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE

The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.

Parallel synthesis of glycomimetic libraries: targeting a C-type lectin.

We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay. Ten library members with inhibitory activities equivalent to that of alpha-methyl mannopyranoside were identified. [reaction: see text]

Chemistry of Cumulenes, 7. Synthesis of Derivatives of 1,2,3,4-Pentatetraene-1,5-dicarboxylic Acid Derivatives via Wittig Reaction with 1-H-Allene-1,3-dicarboxylic Monoester Chlorides

The 1-H-allene-1,3-dicarboxylic monoester chlorides 13a/b as precursors of derivatives of the 1,2,3-butatrienone can be transformed to 1-tert-butyl-5-phenyl-1,2,3,4-pentatetraene-1,5-dicarboxylic diesters 15a-d via Wittig carbonyl olefination.Cleavage of the tert-butoxy group in 15c allowed access to the stable, crystalline 15e, the first derivative of pentatetraenecarboxylic acid.