4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide

Base Information

• Chemical Name: 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide
• CAS No.: 73735-86-1
• Molecular Formula: BrH*C₂₁H₂₅FN₄O
• Molecular Weight: 449.366
• Mol file: 73735-86-1.mol

Synonyms:4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide

Chemical Property of 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide

There total 5 articles about 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxirane (75-21-8,99932-75-9) + 1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]imidazol-2-amine hydrobromide → 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide (73735-86-1)

Guidance literature:

In methanol; water;

Reference yield:

(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine (73734-07-3) → 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide (73735-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 1.) ammonia / 1.) methanol, 2.) methanol, RT, overnight

With ammonia; hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00150a029

Reference yield:

1-chloromethyl-4-fluorobenzene (352-11-4) → 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide (73735-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 1.) ammonia / 1.) methanol, 2.) methanol, RT, overnight

With ammonia; hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00150a029

upstream raw materials:

oxirane

1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

Downstream raw materials:

2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate

Refernces

• 1、 -. "N-Heterocyclyl-4-piperidinamines". . . Retrieved 2008/06/13.