5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine

Base Information

• Chemical Name: 5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine
• CAS No.: 88010-86-0
• Molecular Formula: C₃₆H₃₈N₆O₅
• Molecular Weight: 634.735

Synonyms:5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine

Chemical Property of 5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine

Chemical Property:

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Technology Process of 5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine

There total 6 articles about 5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) → 5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine (88010-86-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 41 percent / 2.) Na / 1.) 90 deg C, 1 h; 2.) MeOH, -10 deg C, 1 h

2: methanol / 2 h

3: pyridine / 2 h

With pyridine; sodium; In methanol;

DOI:10.1021/ja00268a052

Reference yield:

2,2-dimethoxy-1-methylpyrrolidine (39650-82-3) → 5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine (88010-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h

2: pyridine / 2 h

With pyridine; In methanol;

DOI:10.1021/ja00268a052

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + 6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine (88010-85-9) → 5'-O-(di-p-methoxytrityl)-6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine (88010-86-0)

Guidance literature:

With pyridine; for 2h; Yield given;

DOI:10.1021/ja00268a052

upstream raw materials:

N-Methyl-2,2-diethoxypyrrolidine

4,4'-dimethoxytrityl chloride

2'-deoxy-D-adenosine

N⁶-(dimethylamino-methylene)-2'-deoxy-adenosine

Downstream raw materials:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester

Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester

{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[1-methyl-pyrrolidin-(2Z)-ylidene]-amine

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