Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester

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Chemical Name:Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester
CAS No.:88010-87-1
Molecular Formula:C₄₃H₅₄N₇O₆P
Molecular Weight:795.919
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester

There total 3 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 86030-43-5
N,N-diisopropylmethylphosphonamidic chloride

: 88010-86-0
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-ol

: 88010-87-1
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: DOI:10.1016/S0040-4039(00)88067-3

Reference yield:

: 17331-12-3
N⁶-(dimethylamino-methylene)-2'-deoxy-adenosine

: 88010-87-1
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ZnBr₂ / nitromethane; methanol

2: 1.) pyridine, 12 h, water, 2.) pyridine, 5 h, r.t.

3: 95 percent

With zinc dibromide; In methanol; nitromethane;
DOI:10.1016/S0040-4039(00)88067-3

Reference yield:

: 88010-85-9
6-N-(N-methylpyrrolidin-2-ylidene)-2'-deoxyadenosine

: 88010-87-1
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[1-methyl-pyrrolidin-(2E)-ylideneamino]-purin-9-yl}-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ethylenediamine, phenol, H₂O / 6 h / 40 °C

2: 1.) pyridine, 12 h, water, 2.) pyridine, 5 h, r.t.

3: 95 percent

With water; ethylenediamine; phenol;
DOI:10.1016/S0040-4039(00)88067-3