4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

Base Information

Chemical Name:4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide
CAS No.:1202765-92-1
Molecular Formula:C₂₃H₂₂BrN₅O
Molecular Weight:464.365
Hs Code.:

Synonyms:4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

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Chemical Property of 4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

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Technology Process of 4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

There total 6 articles about 4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1202765-94-3
4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

: 1202765-92-1
4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

Guidance literature:: 4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 3h;

With ammonium hydroxide; ammonium chloride; In water; isopropyl alcohol; at 100 ℃; for 2h;

Reference yield:

: 1129-35-7
4-cyanobenzoic acid methyl ester

: 1202765-92-1
4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 °C

1.2: 2.17 h / 0 - 20 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.08 h / 0 °C

2.2: 18 h / 20 °C

3.1: iron; acetic acid / 1 h / 95 °C

4.1: sulfuric acid / 20 - 42 °C

4.2: 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C

5.2: 2 h / 100 °C

With sulfuric acid; sodium hexamethyldisilazane; iron; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 1202765-92-1
4-(3-(2-aminopyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 °C

1.2: 2.17 h / 0 - 20 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.08 h / 0 °C

2.2: 18 h / 20 °C

3.1: iron; acetic acid / 1 h / 95 °C

4.1: sulfuric acid / 20 - 42 °C

4.2: 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C

5.2: 2 h / 100 °C

With sulfuric acid; sodium hexamethyldisilazane; iron; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;