4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

Base Information

Chemical Name:4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide
CAS No.:1202765-94-3
Molecular Formula:C₂₄H₂₃BrN₄OS
Molecular Weight:495.443
Hs Code.:

Synonyms:4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

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Chemical Property of 4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

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Technology Process of 4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

There total 5 articles about 4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 540-88-5
acetic acid tert-butyl ester

: 1202765-90-9
4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-1H-indol-2-yl)benzonitrile

: 144-55-8
sodium hydrogencarbonate

: 1202765-94-3
4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

Guidance literature:: acetic acid tert-butyl ester; 4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-1H-indol-2-yl)benzonitrile; With sulfuric acid; at 20 - 42 ℃;

sodium hydrogencarbonate; In water; at 20 ℃;

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 1202765-94-3
4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 °C

1.2: 2.17 h / 0 - 20 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.08 h / 0 °C

2.2: 18 h / 20 °C

3.1: iron; acetic acid / 1 h / 95 °C

4.1: sulfuric acid / 20 - 42 °C

4.2: 20 °C

With sulfuric acid; sodium hexamethyldisilazane; iron; sodium hydride; acetic acid; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 1129-35-7
4-cyanobenzoic acid methyl ester

: 1202765-94-3
4-(5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-5-bromo-1H-indol-2-yl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 °C

1.2: 2.17 h / 0 - 20 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.08 h / 0 °C

2.2: 18 h / 20 °C

3.1: iron; acetic acid / 1 h / 95 °C

4.1: sulfuric acid / 20 - 42 °C

4.2: 20 °C

With sulfuric acid; sodium hexamethyldisilazane; iron; sodium hydride; acetic acid; In tetrahydrofuran; dimethyl sulfoxide;