Z-L-Val-chloromethylketone

Base Information

Chemical Name:Z-L-Val-chloromethylketone
CAS No.:90105-41-2
Molecular Formula:C14H18 Cl N O3
Molecular Weight:283.755
Hs Code.:
DSSTox Substance ID:DTXSID90552487
Mol file:90105-41-2.mol

Synonyms:Z-L-Val-chloromethylketone;90105-41-2;BENZYL N-[(3S)-1-CHLORO-4-METHYL-2-OXOPENTAN-3-YL]CARBAMATE;SCHEMBL6456168;DTXSID90552487;(S)-benzyl 1-chloro-4-methyl-2-oxopentan-3-ylcarbamate;(S)-Benzyl (1-chloro-4-methyl-2-oxopentan-3-yl)carbamate;Benzyl [(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamate

Suppliers and Price of Z-L-Val-chloromethylketone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of Z-L-Val-chloromethylketone

Chemical Property:

Melting Point:69-74 °C(Solv: ethanol (64-17-5))
Boiling Point:417.6±35.0 °C(Predicted)
PKA:10.69±0.46(Predicted)
PSA：58.89000
Density:1.168±0.06 g/cm3(Predicted)
LogP:2.94970
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:283.0975211
Heavy Atom Count:19
Complexity:301

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)CCl)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES:CC(C)[C@@H](C(=O)CCl)NC(=O)OCC1=CC=CC=C1

Technology Process of Z-L-Val-chloromethylketone

There total 10 articles about Z-L-Val-chloromethylketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 850796-29-1
dimethylsulfoxonium (3S)-2-oxo-3-(benzyloxycarbonylamino)-4-methylpentylide

: 90105-41-2
(S)-1-chloro-3-(benzyloxycarbonylamino)-4-methyl-2-pentanone

Guidance literature:: With methanesulfonic acid; lithium chloride; In tetrahydrofuran; at 70 ℃; for 48h;
DOI:10.1021/jo035733r

Reference yield: 74.0%

: 90105-46-7,28094-73-7
benzyl (S)-(1-diazo-4-methyl-2-oxopentan-3-yl)carbamate

: 90105-41-2
(S)-1-chloro-3-(benzyloxycarbonylamino)-4-methyl-2-pentanone

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 5 ℃; for 0.25h;

Reference yield:

: 593-71-5
Chloroiodomethane

: 24210-19-3
methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate

: 90105-41-2
(S)-1-chloro-3-(benzyloxycarbonylamino)-4-methyl-2-pentanone

Guidance literature:: Chloroiodomethane; methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2.5h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; at -70 - 20 ℃;