2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide

Base Information

• Chemical Name: 2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide
• CAS No.: 403511-45-5
• Molecular Formula: C₁₈H₃₅NO₂Si
• Molecular Weight: 325.567
• Mol file: 403511-45-5.mol

Synonyms:2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide

Chemical Property of 2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide

There total 6 articles about 2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-[(1R,4S,4aR,5S,8R,8aS)-8-(tert-Butyl-dimethyl-silanyloxy)-5-ethyl-1,4,4a,5,6,7,8,8a-octahydro-1,4-methano-naphthalen-5-yl]-N,N-dimethyl-acetamide (403511-44-4) → 2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide (403511-45-5)

Guidance literature:

With sodium hydrogencarbonate; In diphenylether; at 280 ℃;

DOI:10.1016/S0040-4039(01)02075-5

Reference yield:

C13H17BrO2 (403511-40-0) → 2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide (403511-45-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / diphenyl ether / 280 °C

2: 92 percent / H₂ / Pd/C / ethyl acetate

3: 93 percent / Zn / acetic acid; methanol / Heating

4: 94 percent / imidazole / 20 °C

5: 93 percent / NaHCO₃ / diphenyl ether / 280 °C

With 1H-imidazole; hydrogen; sodium hydrogencarbonate; zinc; palladium on activated charcoal; In methanol; diphenylether; acetic acid; ethyl acetate;

DOI:10.1016/S0040-4039(01)02075-5

Reference yield:

C15H19BrO3 → 2-[4-(tert-butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-N,N-dimethyl-acetamide (403511-45-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / K₂CO₃; MeOH / 20 °C

2: 96 percent / diphenyl ether / 280 °C

3: 92 percent / H₂ / Pd/C / ethyl acetate

4: 93 percent / Zn / acetic acid; methanol / Heating

5: 94 percent / imidazole / 20 °C

6: 93 percent / NaHCO₃ / diphenyl ether / 280 °C

With 1H-imidazole; methanol; hydrogen; sodium hydrogencarbonate; potassium carbonate; zinc; palladium on activated charcoal; In methanol; diphenylether; acetic acid; ethyl acetate;

DOI:10.1016/S0040-4039(01)02075-5

upstream raw materials:

2-[(1R,4S,4aR,5S,8R,8aS)-8-(tert-Butyl-dimethyl-silanyloxy)-5-ethyl-1,4,4a,5,6,7,8,8a-octahydro-1,4-methano-naphthalen-5-yl]-N,N-dimethyl-acetamide

C₁₃H₁₇BrO₂

2-((1R,4S,4aR,5S,8R,8aS)-5-Ethyl-8-hydroxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-methano-naphthalen-5-yl)-N,N-dimethyl-acetamide

C₁₇H₂₆BrNO₂

Downstream raw materials:

(1R,4S)-4-Ethyl-4-(2-hydroxy-ethyl)-cyclohex-2-enol

2-[(1S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-ethyl-cyclohex-2-enyl]-ethanol