(4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one

Base Information

• Chemical Name: (4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one
• CAS No.: 1415986-75-2
• Molecular Formula: C₃₁H₃₆N₂O₃
• Molecular Weight: 484.638

Synonyms:(4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one

Chemical Property of (4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one

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Technology Process of (4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one

There total 1 articles about (4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one (113543-30-9) + N,N-dibenzyliminium trifluoroacetate salt → (4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one (1415986-75-2)

Guidance literature:

(S)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one; With titanium tetrachloride; In dichloromethane; at 0 ℃; Inert atmosphere;

With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

N,N-dibenzyliminium trifluoroacetate salt; In dichloromethane; at -80 ℃; for 16h; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/cbdv.201200277

Reference yield: 40.0%

(4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one (1415986-75-2) + ethanethiol (75-08-1) → S-ethyl (2R)-2-(dibenzylamino)methyl-4-methylpentanethioate (1415986-78-5)

Guidance literature:

ethanethiol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

(4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

DOI:10.1002/cbdv.201200277

Reference yield:

(4S)-4-benzyl-3-[(2R)-2-(dibenzylamino)methyl-4-methylpentanoyl]-1,3-oxazolidin-2-one (1415986-75-2) → C24H30N2O3

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol;

DOI:10.1002/cbdv.201200277

upstream raw materials:

(S)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one

Downstream raw materials:

S-ethyl (2R)-2-(dibenzylamino)methyl-4-methylpentanethioate

(2R)-([amino]methyl)-4-methylpentanoic acid

(2R)-2-({[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methyl)-4-methylpentanoic acid

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