(S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone

Base Information

• Chemical Name: (S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone
• CAS No.: 299216-15-2
• Molecular Formula: C₁₄H₁₈N₂O₂
• Molecular Weight: 246.309
• Mol file: 299216-15-2.mol

Synonyms:(S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone

Chemical Property of (S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone

There total 2 articles about (S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-Benzyl-2-oxazolidinone (90719-32-7) → (S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone (299216-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / n-BuLi; O-(mesitylenesulfonyl)hydroxylamine / tetrahydrofuran; hexane / -78 - 20 °C

2: 291 mg / tetrahydrofuran; hexane

With n-butyllithium; mesitylenesulfonylhydroxylamine; In tetrahydrofuran; hexane;

DOI:10.1021/jo050756m

Reference yield:

(S)-3-(methoxycarbonylmethylidene)amino-4-phenylmethyl-2-oxazolidinone (299216-19-6) → (S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone (299216-15-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ZnCl₂; 2-iodopropane; O₂ / Bu₃SnH / CH₂Cl₂; diethyl ether / 48 h / 20 °C

2: 75 percent / n-BuLi; O-(mesitylenesulfonyl)hydroxylamine / tetrahydrofuran; hexane / -78 - 20 °C

3: 291 mg / tetrahydrofuran; hexane

With 2-iodo-propane; n-butyllithium; oxygen; mesitylenesulfonylhydroxylamine; zinc(II) chloride; tri-n-butyl-tin hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

DOI:10.1021/jo050756m

Reference yield: 41.0%

ethyl iodide (75-03-6) + (S)-3-(2'-methylpropylidene)amino-4-phenylmethyl-2-oxazolidinone (299216-15-2) → (4S,3'S)-3-(2'-methyl-3'-pentylamino)-4-phenylmethyl-2-oxazolidinone

Guidance literature:

With indium(III) chloride; dimanganese decacarbonyl; In dichloromethane; at 35 ℃; UV-irradiation;

DOI:10.1021/jo061158q

upstream raw materials:

(S)-4-Benzyl-2-oxazolidinone

(S)-3-(methoxycarbonylmethylidene)amino-4-phenylmethyl-2-oxazolidinone