2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid

Base Information

Chemical Name:2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid
CAS No.:1308662-09-0
Molecular Formula:C₂₃H₃₁N₃O₄S
Molecular Weight:445.583
Hs Code.:

Synonyms:2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid

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Chemical Property of 2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid

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Technology Process of 2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid

There total 8 articles about 2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82072-23-9
3-(bromomethyl)benzaldehyde

: 1308662-09-0
2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / dichloromethane; N,N-dimethyl-formamide / 20 h / 20 °C

2.1: sodium cyanoborohydride; acetic acid / methanol / 16 h / 0 - 20 °C / Inert atmosphere; Cooling with ice

3.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 20 °C

3.2: pH 4.5

With lithium hydroxide monohydrate; sodium cyanoborohydride; caesium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1308662-08-9
2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

: 1308662-09-0
2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid

Guidance literature:: 2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; pH=4.5;

Reference yield:

: 28188-41-2
m-(bromomethyl)benzonitrile

: 1308662-09-0
2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / chlorobenzene; chloroform / 1 h / 5 °C / Cooling with ice

2.1: caesium carbonate / dichloromethane; N,N-dimethyl-formamide / 20 h / 20 °C

3.1: sodium cyanoborohydride; acetic acid / methanol / 16 h / 0 - 20 °C / Inert atmosphere; Cooling with ice

4.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 20 °C

4.2: pH 4.5

With lithium hydroxide monohydrate; diisobutylaluminium hydride; sodium cyanoborohydride; caesium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; chlorobenzene;