4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Base Information

• Chemical Name: 4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide
• CAS No.: 452095-63-5
• Molecular Formula: C₁₅H₁₂N₂O₆S
• Molecular Weight: 348.336

Synonyms:4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Chemical Property of 4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Chemical Property:

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Technology Process of 4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

There total 2 articles about 4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-Hydroxybenzyl alcohol (620-24-6) + 3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (66074-00-8) → 4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (452095-63-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 5 ℃; for 0.5h;

DOI:10.1021/acs.jmedchem.5b00317

Reference yield:

→ 4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (452095-63-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.333333h; Cooling with ice;

Reference yield: 88.7%

succinic acid anhydride (108-30-5) + 4-(3-(hydroxymethyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (452095-63-5) → C19H16N2O9S

Guidance literature:

With dmap; In dichloromethane; at 40 ℃; for 20h;

DOI:10.1021/jm5007534

upstream raw materials:

3-Hydroxybenzyl alcohol

3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Downstream raw materials:

28-(benzyloxy)-28-oxoolean-12-en-3-yl 3-{[5-oxido-4-(phenylsulfonyl)-1,2,5-oxadiazol-3-yl]oxy}benzyl succinate

3-({4-[(3-{[5-oxido-4-(phenylsulfonyl)-1,2,5-oxadiazol-3-yl]oxy}benzyl)oxy]-4-oxobutanoyl}oxy)olean-12-en-28-oic acid

(Z)-4-(3-((2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)methyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

(Z)-4-(3-((2-(5-fluoro-2-methyl-1-(4-(methylsulfonyl)benzylidene)-1H-inden-3-yl)acetoxy)methyl)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

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