(3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide

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Chemical Name:(3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide
CAS No.:1426402-10-9
Molecular Formula:C₂₂H₁₉F₃N₄O₃
Molecular Weight:444.413
Hs Code.:

Synonyms:(3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide

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Chemical Property of (3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide

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Technology Process of (3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide

There total 10 articles about (3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426408-37-8
(3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid

: 1426408-42-5
1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-ylamine

: 1426402-10-9
(3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 3314-35-0
3-Amino-1-phenyl-2-pyrazoline

: 1426402-10-9
(3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloranil / N,N-dimethyl-formamide; 1,4-dioxane / 4.83 h / 20 °C / Cooling with ice

1.2: 1.42 h / 20 °C / Cooling with ice

2.1: acetic acid / 3 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.08 h / -78 °C

3.2: 1.67 h / -78 °C

3.3: 1 h / -78 - 20 °C

4.1: hydroxylamine hydrochloride; triethylamine / water; ethanol / 72 h / 95 °C

5.1: sodium carbonate; tricyclohexylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 2 h / 20 °C

With n-butyllithium; hydroxylamine hydrochloride; palladium diacetate; chloranil; sodium carbonate; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; hexane; water; N,N-dimethyl-formamide; 5.1: |Suzuki Coupling;

Reference yield:

: 1426408-39-0
3-(2,5-dimethyl-1-pyrrol-1-yl)-1-phenyl-1H-pyrazole

: 1426402-10-9
(3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.08 h / -78 °C

1.2: 1.67 h / -78 °C

1.3: 1 h / -78 - 20 °C

2.1: hydroxylamine hydrochloride; triethylamine / water; ethanol / 72 h / 95 °C

3.1: sodium carbonate; tricyclohexylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 2 h / 20 °C

With n-butyllithium; hydroxylamine hydrochloride; palladium diacetate; sodium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; water; N,N-dimethyl-formamide; 3.1: |Suzuki Coupling;