((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide)

Base Information

Chemical Name:((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide)
CAS No.:1426402-13-2
Molecular Formula:C₂₁H₁₇F₃N₄O₃
Molecular Weight:430.386
Hs Code.:

Synonyms:((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide)

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Chemical Property of ((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide)

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Technology Process of ((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide)

There total 12 articles about ((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426408-42-5
1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-ylamine

: (R)-(+)-5-oxo-3-pyrrolidinecarboxylic acid

: 1426402-13-2
((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide)

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1426402-10-9
(3R,4R)-4-methyl-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl]amide

: (R)-(+)-5-oxo-3-pyrrolidinecarboxylic acid

: 1426402-13-2
((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide)

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃;

Reference yield:

: 3314-35-0
3-Amino-1-phenyl-2-pyrazoline

: 1426402-13-2
((R)-5-oxopyrrolidine-3-carboxylic acid [1-phenyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazol-3-yl]amide)

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloranil / N,N-dimethyl-formamide; 1,4-dioxane / 4.83 h / 20 °C / Cooling with ice

1.2: 1.42 h / 20 °C / Cooling with ice

2.1: acetic acid / 3 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.08 h / -78 °C

3.2: 1.67 h / -78 °C

3.3: 1 h / -78 - 20 °C

4.1: hydroxylamine hydrochloride; triethylamine / water; ethanol / 72 h / 95 °C

5.1: sodium carbonate; tricyclohexylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 20 °C

With n-butyllithium; hydroxylamine hydrochloride; palladium diacetate; chloranil; sodium carbonate; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; hexane; water; N,N-dimethyl-formamide; 5.1: |Suzuki Coupling;