2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester

Base Information

Chemical Name:2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester
CAS No.:146307-09-7
Molecular Formula:C₁₉H₂₀ClN₃O₇
Molecular Weight:437.837
Hs Code.:

Synonyms:2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester

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Chemical Property of 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester

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Technology Process of 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester

There total 3 articles about 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 32213-95-9
dimethyl L-aspartate hydrochloride

: 146307-07-5
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoyl chloride

: 146307-09-7
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 0.333333h; Ambient temperature;
DOI:10.3891/acta.chem.scand.46-1204

Reference yield:

: 146307-06-4
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoic acid

: 146307-09-7
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / PCl₅ / toluene / 24 h / 20 °C

2: 92 percent / Et₃N / CH₂Cl₂ / 0.33 h / Ambient temperature

With phosphorus pentachloride; triethylamine; In dichloromethane; toluene;
DOI:10.3891/acta.chem.scand.46-1204

Reference yield:

: 88045-96-9
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoic acid methyl ester

: 146307-09-7
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>succinic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 20 nM ammoniumcarbonate buffer (pH 8.4) / 20 h / 37 °C / porcine liver esterase

2: 98 percent / PCl₅ / toluene / 24 h / 20 °C

3: 92 percent / Et₃N / CH₂Cl₂ / 0.33 h / Ambient temperature

With 20 nM ammoniumcarbonate buffer; phosphorus pentachloride; triethylamine; In dichloromethane; toluene;
DOI:10.3891/acta.chem.scand.46-1204