ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

Base Information

Chemical Name:ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate
CAS No.:1186318-46-6
Molecular Formula:C₁₉H₂₁NO₅
Molecular Weight:343.379
Hs Code.:

Synonyms:ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

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Chemical Property of ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

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Technology Process of ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

There total 3 articles about ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1631-26-1
1-benzyl-1H-pyrrole-2,5-dione

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

: 1186318-46-6
ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentanecarboxylate

Guidance literature:: With silica-supported quinine catalyst; In toluene; at 0 ℃; for 96h; Solvent; Reagent/catalyst; Temperature; stereoselective reaction;
DOI:10.1007/s10562-014-1322-5

Reference yield:

: 1631-26-1
1-benzyl-1H-pyrrole-2,5-dione

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

: 1263036-74-3
ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

: 1263036-73-2
ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

: 1186318-46-6
ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

Guidance literature:: With cinchonine; In toluene; at 20 ℃; for 96h; Solvent; Reagent/catalyst; Time; Overall yield = 89 %; Optical yield = 48 %de; enantioselective reaction;
DOI:10.1007/s10562-012-0915-0

Reference yield:

: 1631-26-1
1-benzyl-1H-pyrrole-2,5-dione

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

: 1263036-74-3
ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

: 1186318-46-6
ethyl 1-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-oxocyclopentane-1-carboxylate

Guidance literature:: With quinine functionalized Fe₃O₄*SiO₂ nanoparticles (MNPs-QN); In toluene; at 0 ℃; for 48h; Overall yield = 86 %; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.cclet.2017.06.022