methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate

Base Information

• Chemical Name: methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate
• CAS No.: 1374779-25-5
• Molecular Formula: C₃₅H₂₉Cl₂FN₄O₄
• Molecular Weight: 659.544
• Mol file: 1374779-25-5.mol

Synonyms:methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate

Chemical Property of methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate

There total 6 articles about methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl 2-amino-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoate (1374779-23-3) + 4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzoic acid (316810-07-8) → methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate (1374779-25-5)

Guidance literature:

4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzoic acid; With thionyl chloride; at 70 ℃; for 5h;

methyl 2-amino-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoate; With dmap; In tetrahydrofuran; Reflux;

Reference yield:

3-Methoxycarbonyl-4-nitrobenzoic acid (64152-09-6) → methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate (1374779-25-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 - 50 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: palladium 10% on activated carbon / methanol; ethyl acetate / 20 °C / 1551.49 Torr

4.1: thionyl chloride / 5 h / 70 °C

4.2: Reflux

With thionyl chloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

5-methyl-2-nitro-benzoic acid methyl ester (20587-30-8) → methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate (1374779-25-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: chromium(VI) oxide; periodic acid / acetonitrile / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 - 50 °C

3.1: triethylamine / tetrahydrofuran / 20 °C

4.1: palladium 10% on activated carbon / methanol; ethyl acetate / 20 °C / 1551.49 Torr

5.1: thionyl chloride / 5 h / 70 °C

5.2: Reflux

With chromium(VI) oxide; thionyl chloride; oxalyl dichloride; periodic acid; triethylamine; N,N-dimethyl-formamide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;

upstream raw materials:

4-Carboxybenzaldehyde

5-methyl-2-nitro-benzoic acid methyl ester

3-Methoxycarbonyl-4-nitrobenzoic acid

methyl 2-amino-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoate

Downstream raw materials:

2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid