2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid

Base Information

Chemical Name:2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid
CAS No.:1374777-48-6
Molecular Formula:C₃₄H₂₇Cl₂FN₄O₄
Molecular Weight:645.517
Hs Code.:

Synonyms:2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid

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Chemical Property of 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid

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Technology Process of 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid

There total 8 articles about 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1374779-25-5
methyl 2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl) benzoate

: 1374777-48-6
2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 3h;

Reference yield:

: 64152-09-6
3-Methoxycarbonyl-4-nitrobenzoic acid

: 1374777-48-6
2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 - 50 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: palladium 10% on activated carbon / methanol; ethyl acetate / 20 °C / 1551.49 Torr

4.1: thionyl chloride / 5 h / 70 °C

4.2: Reflux

5.1: sodium hydroxide / tetrahydrofuran; methanol / 3 h / 70 °C

With thionyl chloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

: 20587-30-8
5-methyl-2-nitro-benzoic acid methyl ester

: 1374777-48-6
2-(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamido)-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: chromium(VI) oxide; periodic acid / acetonitrile / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 - 50 °C

3.1: triethylamine / tetrahydrofuran / 20 °C

4.1: palladium 10% on activated carbon / methanol; ethyl acetate / 20 °C / 1551.49 Torr

5.1: thionyl chloride / 5 h / 70 °C

5.2: Reflux

6.1: sodium hydroxide / tetrahydrofuran; methanol / 3 h / 70 °C

With chromium(VI) oxide; thionyl chloride; oxalyl dichloride; periodic acid; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;