N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide

Base Information

Chemical Name:N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide
CAS No.:323183-40-0
Molecular Formula:C₃₇H₄₆N₄O₅
Molecular Weight:626.796
Hs Code.:

Synonyms:N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide

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Chemical Property of N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide

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Technology Process of N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide

There total 4 articles about N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140645-23-4
1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate

: 323183-39-7
3-(2-[(3,3,3-triphenylpropanoyl)amino]acetylamino)propionic acid

: 323183-40-0
N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 16h;
DOI:10.1021/jm010480k

Reference yield:

: methyl 3-[(2-aminoacetyl)amino]propionate hydrochloride

: 323183-40-0
N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NEt₃ / CHCl₃ / 0.33 h / 20 °C

1.2: 7.75 g / WSC-HCl; HOBt / CHCl₃ / 20 h / 20 °C

2.1: aq. NaOH / methanol; CHCl₃ / 4 h / 20 °C

3.1: 2.27 g / WSC-HCl; HOBt / CHCl₃ / 16 h / 20 °C

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; chloroform;
DOI:10.1021/jm010480k

Reference yield:

: 405161-00-4
methyl 3-(2-[(tert-butoxycarbonyl)amino]acetylamino)propionate

: 323183-40-0
N-(2-[3-([(3R)-1-(tert-butoxycarbonyl)-3-piperidinyl]methyl)amino-3-oxopropyl]amino-2-oxoethyl)-3,3,3-triphenylpropioamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: HCl / methanol / 18 h / 20 °C

2.1: NEt₃ / CHCl₃ / 0.33 h / 20 °C

2.2: 7.75 g / WSC-HCl; HOBt / CHCl₃ / 20 h / 20 °C

3.1: aq. NaOH / methanol; CHCl₃ / 4 h / 20 °C

4.1: 2.27 g / WSC-HCl; HOBt / CHCl₃ / 16 h / 20 °C

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; chloroform;
DOI:10.1021/jm010480k