Technology Process of bis(4-(benzyloxy)-3,5-dimethoxyphenyl)methanol
There total 10 articles about bis(4-(benzyloxy)-3,5-dimethoxyphenyl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(benzyloxy)-5-bromo-1,3-dimethoxybenzene;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
4-(benzyloxy)-3,5-dimethoxybenzaldehyde;
In
tetrahydrofuran;
at -78 ℃;
for 2.33333h;
DOI:10.1039/c3ob00053b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 0.5 h
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
2.2: 2.33 h / -78 °C
With
n-butyllithium; tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c3ob00053b
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine; sodium carbonate / dichloromethane / 48 h / 20 °C
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 0 - 20 °C
4.1: potassium hydroxide / ethanol; water / 2 h / 20 °C
5.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 0.5 h
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
6.2: 2.33 h / -78 °C
With
n-butyllithium; bromine; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
3.1: |Dakin Phenol Oxidation;
DOI:10.1039/c3ob00053b
