4-(Benzyloxy)-3,5-dimethoxybenzaldehyde

Base Information

• Chemical Name: 4-(Benzyloxy)-3,5-dimethoxybenzaldehyde
• CAS No.: 6527-32-8
• Molecular Formula: C16H16O4
• Molecular Weight: 272.301
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID50215586
• Nikkaji Number: J432.150B
• Mol file: 6527-32-8.mol

Synonyms:4-(benzyloxy)-3,5-dimethoxybenzaldehyde;6527-32-8;3,5-dimethoxy-4-phenylmethoxybenzaldehyde;3,5-Dimethoxy-4-(phenylmethoxy)benzaldehyde;Benzaldehyde, 3,5-dimethoxy-4-(phenylmethoxy)-;MFCD00088987;Benzaldehyde, 4-(benzyloxy)-3,5-dimethoxy-;O-benzylsyringaldehyde;SCHEMBL2879297;DTXSID50215586;AGQUHZIDRBKPNN-UHFFFAOYSA-N;3,5-Dimethoxy-4-benzyloxybenzaldehyde;4-benzyloxy-3,5-dimethoxybenzaldehyde;AKOS001144819;CS-W001017;DS-9223;4-Benzyloxy-3,5-dimethoxy-benzaldehyde;AC-36910;SY045904;EN300-14955;A867696;4-(benzyloxy)-3,5-dimethoxybenzaldehyde, AldrichCPR;Z111542050

Chemical Property of 4-(Benzyloxy)-3,5-dimethoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 2.24E-07mmHg at 25°C
• Melting Point: 63 °C(Solv: ethanol (64-17-5))
• Boiling Point: 423.4°C at 760 mmHg
• Flash Point: 188.1°C
• PSA: 44.76000
• Density: 1.164g/cm³
• LogP: 3.09530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 272.10485899
• Heavy Atom Count: 20
• Complexity: 274

Purity/Quality:

97% ^*data from raw suppliers

4-(Benzyloxy)-3,5-dimethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OCC2=CC=CC=C2)OC)C=O

Technology Process of 4-(Benzyloxy)-3,5-dimethoxybenzaldehyde

There total 12 articles about 4-(Benzyloxy)-3,5-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

benzyl bromide (100-39-0) + syringic aldehyde (134-96-3) → 4-(benzyloxy)-3,5-dimethoxybenzaldehyde (6527-32-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1002/anie.201107020

Reference yield: 97.0%

benzyl chloride (100-44-7) + syringic aldehyde (134-96-3) → 4-(benzyloxy)-3,5-dimethoxybenzaldehyde (6527-32-8)

Guidance literature:

With dmap; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo502685k

Reference yield: 89.0%

4-benzyloxy-3,5-dimethoxybenzyl alcohol (2176-18-3) → 4-(benzyloxy)-3,5-dimethoxybenzaldehyde (6527-32-8)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; for 1h;

DOI:10.1039/P19810002002

upstream raw materials:

4-benzyloxy-3,5-dimethoxybenzoic acid chloride

4-benzyloxy-3,5-dimethoxybenzyl alcohol

benzyl bromide

syringic aldehyde

Downstream raw materials:

(S)-(E)-(4-benzyloxy-3,5-dimethoxybenzylidene)-3-(3,4,5-trimethoxybenzyl)butanolide

1,3-Dimethoxy-2-benzyloxy-5-<2-nitro-1-hydroxy-aethyl>-benzol

2-(benzyloxy)-1,3-dimethoxy-5-(2-nitroethenyl)benzene

2-(4-Benzyloxy-3,5-dimethoxy-benzylidene)-cyclopent-4-ene-1,3-dione