(+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid

Base Information

Chemical Name:(+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid
CAS No.:145215-54-9
Molecular Formula:C₁₄H₁₅ClO₂Se
Molecular Weight:329.685
Hs Code.:

Synonyms:(+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid

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Chemical Property of (+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid

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Technology Process of (+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid

There total 3 articles about (+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 20541-49-5
bis(p-chlorophenyl) diselenide

: 145215-53-8
(+/-)-syn-3-(1-methylprop-2-ynyl)tetrahydrofuran-2-one

: 145215-54-9
(+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; In tetrahydrofuran; for 1.5h; Heating;
DOI:10.1016/S0040-4039(00)60942-5

Reference yield:

: 145215-52-7
(+/-)-syn-3-[2-(2-bromoethyl)-3-methyl-5-(trimethylsilanyl)pent-4-ynoyl]oxazolidin-2-one

: 145215-54-9
(+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 79 percent / H₂O₂; LiOH*H₂O / H₂O; tetrahydrofuran / 0.08 h / 0 °C

2.1: 86 percent / TBAF / tetrahydrofuran / 0 °C

3.1: NaH / tetrahydrofuran / 1.5 h / Heating

3.2: 72 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / Heating

With lithium hydroxide; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hydride; In tetrahydrofuran; water;
DOI:10.1021/jo005531k

Reference yield:

: (+/-)-syn-3-[1-methyl-3-(trimethylsilanyl)prop-2-ynyl]tetrahydrofuran-2-one

: 145215-54-9
(+/-)-syn-2-[2-(4-chlorophenylselanyl)ethyl]-3-methyl-pent-4-ynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / TBAF / tetrahydrofuran / 0 °C

2.1: NaH / tetrahydrofuran / 1.5 h / Heating

2.2: 72 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / Heating

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo005531k