2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester

Base Information

• Chemical Name: 2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester
• CAS No.: 1600513-78-7
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.251
• Mol file: 1600513-78-7.mol

Synonyms:2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester

Chemical Property of 2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester

There total 1 articles about 2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-(3-methylphenyl)-pyrrolidine-2,5-dione + methyl chloroformate (79-22-1) → 2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester (1600513-78-7)

Guidance literature:

With triethylamine; In acetone; at 20 ℃; for 0.5h; Reflux;

DOI:10.1016/j.tetlet.2014.03.021

Reference yield:

2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester (1600513-78-7) + methylmagnesium chloride (676-58-4) → C15H17NO2

Guidance literature:

methylmagnesium chloride; With bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; diethyl ether; at -10 - 0 ℃; for 1h; Schlenk technique; Inert atmosphere;

2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester; In tetrahydrofuran; at 65 ℃; for 22h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.03.021

Reference yield:

dimethyltitanocene (1271-66-5) + 2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester (1600513-78-7) → C14H15NO3 + C14H15NO3

Guidance literature:

dimethyltitanocene; 2,5-dioxo-3-m-tolyl-pyrrolidine-1-carboxylic acid methyl ester; In tetrahydrofuran; at 65 ℃;

With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2014.03.021

upstream raw materials:

methyl chloroformate