7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one

Base Information

Chemical Name:7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one
CAS No.:1356353-35-9
Molecular Formula:C₁₆H₁₂F₃N₃O₃S
Molecular Weight:383.351
Hs Code.:

Synonyms:7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one

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Chemical Property of 7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one

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Technology Process of 7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one

There total 6 articles about 7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849805-25-0
methyl 2-amino-6-chloropyridine-3-carboxylate

: 1236764-32-1
1-isothiocyanato-4-(2,2,2-trifluoroethoxy)benzene

: 124-41-4
sodium methylate

: 1356353-35-9
7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one

Guidance literature:: methyl 2-amino-6-chloropyridine-3-carboxylate; 1-isothiocyanato-4-(2,2,2-trifluoroethoxy)benzene; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; Cooling with ice;

With hydrogenchloride; In water; N,N-dimethyl-formamide; mineral oil;

sodium methylate; In methanol; for 0.5h; Reflux;

Reference yield:

: 65515-28-8
methyl 2,6-dichloronicotinate

: 1356353-35-9
7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

2.1: trifluoroacetic acid / 2 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice

3.3: 0.5 h / Reflux

With copper(l) iodide; sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1356353-33-7
methyl 6-chloro-2-[(4-methoxybenzyl)amino]pyridine-3-carboxylate

: 1356353-35-9
7-methoxy-2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice

2.3: 0.5 h / Reflux

With sodium hydride; trifluoroacetic acid; In N,N-dimethyl-formamide; mineral oil;