7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Name:7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid
CAS No.:1356331-77-5
Molecular Formula:C₂₇H₃₁N₃O₂
Molecular Weight:429.562
Hs Code.:

Synonyms:7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Property of 7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Technology Process of 7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

There total 8 articles about 7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356332-90-5
7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid ethyl ester

: 1356331-77-5
7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: 7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid ethyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 70 ℃; for 18h;

With hydrogenchloride; In water; pH=4;

Reference yield:

: 452-58-4
2,3-Diaminopyridine

: 1356331-77-5
7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1 h / 120 °C / Inert atmosphere

2.1: trichlorophosphate / 8 h / 110 °C

3.1: caesium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 64 h / 20 - 70 °C / Inert atmosphere

4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 150 °C / Inert atmosphere

5.1: ammonium formate / 10% palladium hydroxide on charcoal / methanol / 1 h / Inert atmosphere; Reflux

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 18 h / 70 °C

7.2: pH 4

With water; ammonium formate; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; lithium hydroxide; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10% palladium hydroxide on charcoal; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dichloro-ethane;

Reference yield:

: 2067-84-7
NSC 91561

: 1356331-77-5
7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 8 h / 110 °C

2.1: caesium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 64 h / 20 - 70 °C / Inert atmosphere

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 150 °C / Inert atmosphere

4.1: ammonium formate / 10% palladium hydroxide on charcoal / methanol / 1 h / Inert atmosphere; Reflux

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 18 h / 70 °C

6.2: pH 4

With water; ammonium formate; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; lithium hydroxide; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10% palladium hydroxide on charcoal; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dichloro-ethane;