Technology Process of 7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid ethyl ester
There total 7 articles about 7-(2-phenyl-3-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1 h / 120 °C / Inert atmosphere
2: trichlorophosphate / 8 h / 110 °C
3: caesium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 64 h / 20 - 70 °C / Inert atmosphere
4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 150 °C / Inert atmosphere
5: ammonium formate / 10% palladium hydroxide on charcoal / methanol / 1 h / Inert atmosphere; Reflux
6: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
With
ammonium formate; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); 10% palladium hydroxide on charcoal; tricyclohexylphosphine;
In
1,4-dioxane; methanol; 1,2-dichloro-ethane;
