phenyl-d5 acetic chloride

Base Information

• Chemical Name: phenyl-d5 acetic chloride
• CAS No.: 216966-11-9
• Molecular Formula: C₈H₇ClO
• Molecular Weight: 159.556
• Mol file: 216966-11-9.mol

Synonyms:phenyl-d5 acetic chloride

Chemical Property of phenyl-d5 acetic chloride

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl-d5 acetic chloride

There total 6 articles about phenyl-d5 acetic chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2H5-phenylacetic acid (104182-98-1) → phenyl-d5 acetic chloride (216966-11-9)

Guidance literature:

With thionyl chloride;

DOI:10.1021/jo011047l

Reference yield:

2H5-phenylacetic acid (104182-98-1) + sodium hydrogencarbonate (144-55-8) → phenyl-d5 acetic chloride (216966-11-9)

Guidance literature:

²H₅-phenylacetic acid; With thionyl chloride; at 20 ℃; for 24h;

sodium hydrogencarbonate;

Reference yield:

bromobenzene-d5 (4165-57-5) → phenyl-d5 acetic chloride (216966-11-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 75 °C

1.2: 6 h / 0 - 25 °C

2.1: periodic acid; pyridinium chlorochromate / acetonitrile / 3 h / 25 °C

3.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 25 °C

With thionyl chloride; magnesium; periodic acid; N,N-dimethyl-formamide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1002/anie.201711108

upstream raw materials:

²H₅-phenylacetic acid

5>Benzylchlorid

2-(2,3,4,5,6-pentadeuteriophenyl)acetonitrile

sodium hydrogencarbonate